Creatinine Clearance

Creatin: Mainly in the muscle

Non-essential: can be synthesized in the body from argnine, methionine & glycine

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Creatine phosphate

Is a stable compound
ATP ----> produce & use, never store it
Important in burst activity (emergency)
Phosphor creatine + ADP -----> Energy

Every thing has a 1/2 life time except DNA

Male > Female
Youth > Old

Creatinine is carried in the blood (v. soluble)

Significance is in the creatinine clearance rate (indicates kidney function) if kidney is impaired ---> increse in blood

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Azathionine ----> increse creatinine serum

If the problem was:

Infection----> give antibiotics ---> reversible

Immune ----> can't do any thing ----> irreversible

Ketonemia (as in diabetes) is an acidity state & it causes a v. great damage to the kidney

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BUN ----> used to assist the liver
Creatinine ---> used to assist the kidney

BUN: ----> in kidney problems but it is specific for the liver
Creatinine: used only for kidney problems